diff --git a/src/app/access-control/epeople-registry/epeople-registry.component.html b/src/app/access-control/epeople-registry/epeople-registry.component.html
index c054a5dd55e..498ecf0c9a2 100644
--- a/src/app/access-control/epeople-registry/epeople-registry.component.html
+++ b/src/app/access-control/epeople-registry/epeople-registry.component.html
@@ -74,12 +74,24 @@ <h2 id="search" class="border-bottom pb-2">
                           title="{{labelPrefix + 'table.edit.buttons.edit' | translate: { name: dsoNameService.getName(epersonDto.eperson) } }}">
                           <i class="fas fa-edit fa-fw"></i>
                         </button>
-                        @if (epersonDto.ableToDelete) {
-                          <button (click)="deleteEPerson(epersonDto.eperson)"
-                            class="delete-button btn btn-outline-danger btn-sm access-control-deleteEPersonButton"
-                            title="{{labelPrefix + 'table.edit.buttons.remove' | translate: { name: dsoNameService.getName(epersonDto.eperson) } }}">
-                            <i class="fas fa-trash-alt fa-fw"></i>
-                          </button>
+                        @if (epersonDto.ableToDelete && currentAuthenticatedUserId) {
+                          @if (isCurrentUser(epersonDto.eperson)) {
+                            <span tabindex="0" [ngbTooltip]="selfDeleteWarningLabel | translate" container="body">
+                              <button [dsBtnDisabled]="true"
+                                tabindex="-1"
+                                [attr.aria-label]="selfDeleteWarningLabel | translate"
+                                class="delete-button btn btn-outline-danger btn-sm access-control-deleteEPersonButton"
+                                type="button">
+                                <i class="fas fa-trash-alt fa-fw"></i>
+                              </button>
+                            </span>
+                          } @else {
+                            <button (click)="deleteEPerson(epersonDto.eperson)"
+                              class="delete-button btn btn-outline-danger btn-sm access-control-deleteEPersonButton"
+                              title="{{labelPrefix + 'table.edit.buttons.remove' | translate: { name: dsoNameService.getName(epersonDto.eperson) } }}">
+                              <i class="fas fa-trash-alt fa-fw"></i>
+                            </button>
+                          }
                         }
                       </div>
                     </td>
diff --git a/src/app/access-control/epeople-registry/epeople-registry.component.spec.ts b/src/app/access-control/epeople-registry/epeople-registry.component.spec.ts
index 20a066dbf7e..2efa0c3bd78 100644
--- a/src/app/access-control/epeople-registry/epeople-registry.component.spec.ts
+++ b/src/app/access-control/epeople-registry/epeople-registry.component.spec.ts
@@ -30,6 +30,7 @@ import {
   of,
 } from 'rxjs';
 
+import { AuthService } from '../../core/auth/auth.service';
 import { AuthorizationDataService } from '../../core/data/feature-authorization/authorization-data.service';
 import { FindListOptions } from '../../core/data/find-list-options.model';
 import {
@@ -57,6 +58,7 @@ import {
 import { NotificationsServiceStub } from '../../shared/testing/notifications-service.stub';
 import { PaginationServiceStub } from '../../shared/testing/pagination-service.stub';
 import { EPeopleRegistryComponent } from './epeople-registry.component';
+import { EPersonDeleteGuardService } from './eperson-delete-guard.service';
 import { EPersonFormComponent } from './eperson-form/eperson-form.component';
 
 describe('EPeopleRegistryComponent', () => {
@@ -67,6 +69,8 @@ describe('EPeopleRegistryComponent', () => {
   let mockEPeople: EPerson[];
   let ePersonDataServiceStub: any;
   let authorizationService: AuthorizationDataService;
+  let authService: jasmine.SpyObj<AuthService>;
+  let deleteGuard: jasmine.SpyObj<EPersonDeleteGuardService>;
   let modalService: NgbModal;
   let paginationService: PaginationServiceStub;
 
@@ -149,6 +153,12 @@ describe('EPeopleRegistryComponent', () => {
     });
     builderService = getMockFormBuilderService();
 
+    authService = jasmine.createSpyObj('authService', ['getAuthenticatedUserFromStore']);
+    authService.getAuthenticatedUserFromStore.and.returnValue(of(Object.assign(new EPerson(), { id: 'different-user-id' })));
+    deleteGuard = jasmine.createSpyObj('deleteGuard', ['isCurrentUser', 'getDeleteWarningLabel', 'isSelfDeletionError', 'showSelfDeleteNotification']);
+    deleteGuard.isCurrentUser.and.callFake((ePerson: EPerson, currentId: string) => !!ePerson?.id && ePerson.id === currentId);
+    deleteGuard.getDeleteWarningLabel.and.returnValue(of(undefined));
+    deleteGuard.isSelfDeletionError.and.returnValue(false);
     paginationService = new PaginationServiceStub();
     TestBed.configureTestingModule({
       imports: [CommonModule, NgbModule, FormsModule, ReactiveFormsModule, BrowserModule, RouterTestingModule.withRoutes([]),
@@ -157,6 +167,8 @@ describe('EPeopleRegistryComponent', () => {
         { provide: EPersonDataService, useValue: ePersonDataServiceStub },
         { provide: NotificationsService, useValue: new NotificationsServiceStub() },
         { provide: AuthorizationDataService, useValue: authorizationService },
+        { provide: AuthService, useValue: authService },
+        { provide: EPersonDeleteGuardService, useValue: deleteGuard },
         { provide: FormBuilderService, useValue: builderService },
         { provide: Router, useValue: new RouterMock() },
         { provide: RequestService, useValue: jasmine.createSpyObj('requestService', ['removeByHrefSubstring']) },
@@ -257,6 +269,25 @@ describe('EPeopleRegistryComponent', () => {
         });
       });
     });
+
+    describe('when the ePerson is the currently authenticated user', () => {
+      beforeEach(() => {
+        component.currentAuthenticatedUserId = EPersonMock.id;
+        fixture.detectChanges();
+      });
+
+      it('renders the delete button for that row as disabled', () => {
+        const deleteButtons = fixture.debugElement.queryAll(By.css('.access-control-deleteEPersonButton'));
+        const disabled = deleteButtons.filter((button) => button.nativeElement.getAttribute('aria-disabled') === 'true');
+        expect(disabled.length).toBe(1);
+      });
+
+      it('notifies instead of opening the confirmation modal', () => {
+        component.deleteEPerson(EPersonMock);
+        expect(deleteGuard.showSelfDeleteNotification).toHaveBeenCalled();
+        expect(modalService.open).not.toHaveBeenCalled();
+      });
+    });
   });
 
 
diff --git a/src/app/access-control/epeople-registry/epeople-registry.component.ts b/src/app/access-control/epeople-registry/epeople-registry.component.ts
index d4a96fa826d..585893f763a 100644
--- a/src/app/access-control/epeople-registry/epeople-registry.component.ts
+++ b/src/app/access-control/epeople-registry/epeople-registry.component.ts
@@ -15,7 +15,10 @@ import {
   Router,
   RouterModule,
 } from '@angular/router';
-import { NgbModal } from '@ng-bootstrap/ng-bootstrap';
+import {
+  NgbModal,
+  NgbTooltipModule,
+} from '@ng-bootstrap/ng-bootstrap';
 import {
   TranslateModule,
   TranslateService,
@@ -32,6 +35,7 @@ import {
   take,
 } from 'rxjs/operators';
 
+import { AuthService } from '../../core/auth/auth.service';
 import { DSONameService } from '../../core/breadcrumbs/dso-name.service';
 import { AuthorizationDataService } from '../../core/data/feature-authorization/authorization-data.service';
 import { FeatureID } from '../../core/data/feature-authorization/feature-id';
@@ -51,6 +55,7 @@ import {
   getFirstCompletedRemoteData,
 } from '../../core/shared/operators';
 import { PageInfo } from '../../core/shared/page-info.model';
+import { BtnDisabledDirective } from '../../shared/btn-disabled.directive';
 import { ConfirmationModalComponent } from '../../shared/confirmation-modal/confirmation-modal.component';
 import { hasValue } from '../../shared/empty.util';
 import { ThemedLoadingComponent } from '../../shared/loading/themed-loading.component';
@@ -61,6 +66,10 @@ import {
   getEPersonEditRoute,
   getEPersonsRoute,
 } from '../access-control-routing-paths';
+import {
+  EPersonDeleteGuardService,
+  SELF_DELETE_WARNING_LABEL,
+} from './eperson-delete-guard.service';
 import { EPersonFormComponent } from './eperson-form/eperson-form.component';
 
 @Component({
@@ -68,7 +77,9 @@ import { EPersonFormComponent } from './eperson-form/eperson-form.component';
   templateUrl: './epeople-registry.component.html',
   imports: [
     AsyncPipe,
+    BtnDisabledDirective,
     EPersonFormComponent,
+    NgbTooltipModule,
     NgClass,
     PaginationComponent,
     ReactiveFormsModule,
@@ -85,6 +96,9 @@ import { EPersonFormComponent } from './eperson-form/eperson-form.component';
 export class EPeopleRegistryComponent implements OnInit, OnDestroy {
 
   labelPrefix = 'admin.access-control.epeople.';
+  selfDeleteWarningLabel = SELF_DELETE_WARNING_LABEL;
+
+  currentAuthenticatedUserId: string;
 
   /**
    * A list of all the current EPeople within the repository or the result of the search
@@ -138,6 +152,8 @@ export class EPeopleRegistryComponent implements OnInit, OnDestroy {
               private translateService: TranslateService,
               private notificationsService: NotificationsService,
               private authorizationService: AuthorizationDataService,
+              private authService: AuthService,
+              private deleteGuard: EPersonDeleteGuardService,
               private formBuilder: UntypedFormBuilder,
               private router: Router,
               private modalService: NgbModal,
@@ -164,6 +180,9 @@ export class EPeopleRegistryComponent implements OnInit, OnDestroy {
     this.searching$.next(true);
     this.search({ scope: this.currentSearchScope, query: this.currentSearchQuery });
     this.activeEPerson$ = this.epersonService.getActiveEPerson();
+    this.subs.push(this.authService.getAuthenticatedUserFromStore().subscribe((currentUser: EPerson) => {
+      this.currentAuthenticatedUserId = currentUser?.id;
+    }));
     this.subs.push(this.ePeople$.pipe(
       switchMap((epeople: PaginatedList<EPerson>) => {
         if (epeople.pageInfo.totalElements > 0) {
@@ -236,30 +255,52 @@ export class EPeopleRegistryComponent implements OnInit, OnDestroy {
    */
   deleteEPerson(ePerson: EPerson) {
     if (hasValue(ePerson.id)) {
-      const modalRef = this.modalService.open(ConfirmationModalComponent);
-      modalRef.componentInstance.name = this.dsoNameService.getName(ePerson);
-      modalRef.componentInstance.headerLabel = 'confirmation-modal.delete-eperson.header';
-      modalRef.componentInstance.infoLabel = 'confirmation-modal.delete-eperson.info';
-      modalRef.componentInstance.cancelLabel = 'confirmation-modal.delete-eperson.cancel';
-      modalRef.componentInstance.confirmLabel = 'confirmation-modal.delete-eperson.confirm';
-      modalRef.componentInstance.brandColor = 'danger';
-      modalRef.componentInstance.confirmIcon = 'fas fa-trash';
-      modalRef.componentInstance.response.pipe(take(1)).subscribe((confirm: boolean) => {
-        if (confirm) {
-          if (hasValue(ePerson.id)) {
+      if (!hasValue(this.currentAuthenticatedUserId)) {
+        return;
+      }
+
+      if (this.isCurrentUser(ePerson)) {
+        this.deleteGuard.showSelfDeleteNotification();
+        return;
+      }
+
+      this.deleteGuard.getDeleteWarningLabel(ePerson).pipe(take(1)).subscribe((warningLabel: string | undefined) => {
+        const modalRef = this.modalService.open(ConfirmationModalComponent);
+        modalRef.componentInstance.name = this.dsoNameService.getName(ePerson);
+        modalRef.componentInstance.headerLabel = 'confirmation-modal.delete-eperson.header';
+        modalRef.componentInstance.infoLabel = 'confirmation-modal.delete-eperson.info';
+        modalRef.componentInstance.warningLabel = warningLabel;
+        modalRef.componentInstance.cancelLabel = 'confirmation-modal.delete-eperson.cancel';
+        modalRef.componentInstance.confirmLabel = 'confirmation-modal.delete-eperson.confirm';
+        modalRef.componentInstance.brandColor = 'danger';
+        modalRef.componentInstance.confirmIcon = 'fas fa-trash';
+        modalRef.componentInstance.response.pipe(take(1)).subscribe((confirm: boolean) => {
+          if (confirm) {
             this.epersonService.deleteEPerson(ePerson).pipe(getFirstCompletedRemoteData()).subscribe((restResponse: RemoteData<NoContent>) => {
               if (restResponse.hasSucceeded) {
                 this.notificationsService.success(this.translateService.get(this.labelPrefix + 'notification.deleted.success', { name: this.dsoNameService.getName(ePerson) }));
+              } else if (this.isCurrentUser(ePerson) || this.deleteGuard.isSelfDeletionError(restResponse)) {
+                this.deleteGuard.showSelfDeleteNotification();
               } else {
-                this.notificationsService.error(this.translateService.get(this.labelPrefix + 'notification.deleted.success', { id: ePerson.id, statusCode: restResponse.statusCode, errorMessage: restResponse.errorMessage }));
+                this.notificationsService.error(this.translateService.get(this.labelPrefix + 'notification.deleted.failure', {
+                  name: this.dsoNameService.getName(ePerson),
+                  id: ePerson.id,
+                  statusCode: restResponse.statusCode,
+                  errorMessage: restResponse.errorMessage,
+                  restResponse,
+                }));
               }
             });
           }
-        }
+        });
       });
     }
   }
 
+  isCurrentUser(ePerson: EPerson): boolean {
+    return this.deleteGuard.isCurrentUser(ePerson, this.currentAuthenticatedUserId);
+  }
+
   /**
    * Unsub all subscriptions
    */
diff --git a/src/app/access-control/epeople-registry/eperson-delete-guard.service.spec.ts b/src/app/access-control/epeople-registry/eperson-delete-guard.service.spec.ts
new file mode 100644
index 00000000000..1c2fd4b5cd8
--- /dev/null
+++ b/src/app/access-control/epeople-registry/eperson-delete-guard.service.spec.ts
@@ -0,0 +1,158 @@
+import {
+  fakeAsync,
+  TestBed,
+  tick,
+} from '@angular/core/testing';
+import { TranslateService } from '@ngx-translate/core';
+import {
+  of,
+  throwError as observableThrowError,
+} from 'rxjs';
+
+import { AuthorizationDataService } from '../../core/data/feature-authorization/authorization-data.service';
+import { FeatureID } from '../../core/data/feature-authorization/feature-id';
+import { buildPaginatedList } from '../../core/data/paginated-list.model';
+import { DSpaceObject } from '../../core/shared/dspace-object.model';
+import { PageInfo } from '../../core/shared/page-info.model';
+import { SearchService } from '../../core/shared/search/search.service';
+import { WorkflowItemDataService } from '../../core/submission/workflowitem-data.service';
+import { WorkspaceitemDataService } from '../../core/submission/workspaceitem-data.service';
+import { NotificationsService } from '../../shared/notifications/notifications.service';
+import {
+  createFailedRemoteDataObject$,
+  createSuccessfulRemoteDataObject$,
+} from '../../shared/remote-data.utils';
+import { SearchObjects } from '../../shared/search/models/search-objects.model';
+import { EPersonMock } from '../../shared/testing/eperson.mock';
+import { NotificationsServiceStub } from '../../shared/testing/notifications-service.stub';
+import { EPersonDeleteGuardService } from './eperson-delete-guard.service';
+
+describe('EPersonDeleteGuardService', () => {
+  let service: EPersonDeleteGuardService;
+  let authorizationService: jasmine.SpyObj<AuthorizationDataService>;
+  let workspaceItemDataService: jasmine.SpyObj<WorkspaceitemDataService>;
+  let workflowItemDataService: jasmine.SpyObj<WorkflowItemDataService>;
+  let searchService: jasmine.SpyObj<SearchService>;
+  let notificationsService: NotificationsServiceStub;
+  let translateService: jasmine.SpyObj<TranslateService>;
+
+  const remoteList = (totalElements: number) => createSuccessfulRemoteDataObject$(
+    buildPaginatedList(new PageInfo({ elementsPerPage: 1, totalElements, totalPages: 1, currentPage: 1 }), []),
+  );
+  const searchObjects = (totalElements: number) => createSuccessfulRemoteDataObject$(Object.assign(
+    new SearchObjects<DSpaceObject>(),
+    buildPaginatedList(new PageInfo({ elementsPerPage: 1, totalElements, totalPages: 1, currentPage: 1 }), []),
+  ));
+
+  beforeEach(() => {
+    authorizationService = jasmine.createSpyObj('authorizationService', ['isAuthorized']);
+    authorizationService.isAuthorized.and.returnValue(of(false));
+    workspaceItemDataService = jasmine.createSpyObj('workspaceItemDataService', ['searchBy']);
+    workspaceItemDataService.searchBy.and.returnValue(remoteList(0));
+    workflowItemDataService = jasmine.createSpyObj('workflowItemDataService', ['searchBy']);
+    workflowItemDataService.searchBy.and.returnValue(remoteList(0));
+    searchService = jasmine.createSpyObj('searchService', ['search']);
+    searchService.search.and.returnValue(searchObjects(0));
+    notificationsService = new NotificationsServiceStub();
+    translateService = jasmine.createSpyObj('translateService', ['get']);
+    translateService.get.and.callFake((key: string) => of(key));
+
+    TestBed.configureTestingModule({
+      providers: [
+        EPersonDeleteGuardService,
+        { provide: AuthorizationDataService, useValue: authorizationService },
+        { provide: WorkspaceitemDataService, useValue: workspaceItemDataService },
+        { provide: WorkflowItemDataService, useValue: workflowItemDataService },
+        { provide: SearchService, useValue: searchService },
+        { provide: NotificationsService, useValue: notificationsService },
+        { provide: TranslateService, useValue: translateService },
+      ],
+    });
+    service = TestBed.inject(EPersonDeleteGuardService);
+  });
+
+  describe('isCurrentUser', () => {
+    it('is true only when the ids match', () => {
+      expect(service.isCurrentUser(EPersonMock, EPersonMock.id)).toBeTrue();
+      expect(service.isCurrentUser(EPersonMock, 'someone-else')).toBeFalse();
+      expect(service.isCurrentUser(undefined, EPersonMock.id)).toBeFalsy();
+    });
+  });
+
+  describe('getDeleteWarningLabel', () => {
+    it('returns undefined when the user is neither a submitter nor an admin', fakeAsync(() => {
+      let label: string | undefined = 'unset';
+      service.getDeleteWarningLabel(EPersonMock).subscribe((value) => label = value);
+      tick();
+      expect(label).toBeUndefined();
+    }));
+
+    it('returns the submitter warning when the user has submitted items', fakeAsync(() => {
+      workspaceItemDataService.searchBy.and.returnValue(remoteList(1));
+      let label: string;
+      service.getDeleteWarningLabel(EPersonMock).subscribe((value) => label = value);
+      tick();
+      expect(label).toBe('admin.access-control.epeople.delete.warning.submitter');
+    }));
+
+    it('returns the admin warning, querying the AdministratorOf feature for the target user', fakeAsync(() => {
+      authorizationService.isAuthorized.and.returnValue(of(true));
+      let label: string;
+      service.getDeleteWarningLabel(EPersonMock).subscribe((value) => label = value);
+      tick();
+      expect(authorizationService.isAuthorized).toHaveBeenCalledWith(FeatureID.AdministratorOf, undefined, EPersonMock.id);
+      expect(label).toBe('admin.access-control.epeople.delete.warning.admin');
+    }));
+
+    it('returns the combined warning when both apply', fakeAsync(() => {
+      workspaceItemDataService.searchBy.and.returnValue(remoteList(1));
+      authorizationService.isAuthorized.and.returnValue(of(true));
+      let label: string;
+      service.getDeleteWarningLabel(EPersonMock).subscribe((value) => label = value);
+      tick();
+      expect(label).toBe('admin.access-control.epeople.delete.warning.submitterAndAdmin');
+    }));
+
+    it('degrades each probe to false on error so a failed lookup never blocks the delete', fakeAsync(() => {
+      workspaceItemDataService.searchBy.and.returnValue(observableThrowError(() => new Error('boom')));
+      searchService.search.and.returnValue(observableThrowError(() => new Error('boom')));
+      authorizationService.isAuthorized.and.returnValue(observableThrowError(() => new Error('boom')));
+      let emitted = false;
+      let label: string | undefined = 'unset';
+      service.getDeleteWarningLabel(EPersonMock).subscribe((value) => {
+        emitted = true;
+        label = value;
+      });
+      tick();
+      expect(emitted).toBeTrue();
+      expect(label).toBeUndefined();
+    }));
+  });
+
+  describe('isSelfDeletionError', () => {
+    it('recognises the backend self-delete rejection', fakeAsync(() => {
+      let rd;
+      createFailedRemoteDataObject$('You, as admin user, cannot delete yourself', 400).subscribe((value) => rd = value);
+      tick();
+      expect(service.isSelfDeletionError(rd)).toBeTrue();
+    }));
+
+    it('ignores other failures', fakeAsync(() => {
+      let rd;
+      createFailedRemoteDataObject$('server error', 500).subscribe((value) => rd = value);
+      tick();
+      expect(service.isSelfDeletionError(rd)).toBeFalsy();
+      expect(service.isSelfDeletionError(null)).toBeFalsy();
+    }));
+  });
+
+  describe('showSelfDeleteNotification', () => {
+    it('emits the self-delete error notification', () => {
+      service.showSelfDeleteNotification();
+      expect(notificationsService.error).toHaveBeenCalled();
+      let translatedKey: string;
+      notificationsService.error.calls.mostRecent().args[0].subscribe((value) => translatedKey = value);
+      expect(translatedKey).toBe('admin.access-control.epeople.notification.deleted.forbidden.self');
+    });
+  });
+});
diff --git a/src/app/access-control/epeople-registry/eperson-delete-guard.service.ts b/src/app/access-control/epeople-registry/eperson-delete-guard.service.ts
new file mode 100644
index 00000000000..553c1a54441
--- /dev/null
+++ b/src/app/access-control/epeople-registry/eperson-delete-guard.service.ts
@@ -0,0 +1,153 @@
+import { Injectable } from '@angular/core';
+import { TranslateService } from '@ngx-translate/core';
+import {
+  combineLatest,
+  Observable,
+  of,
+} from 'rxjs';
+import {
+  catchError,
+  map,
+} from 'rxjs/operators';
+
+import { RequestParam } from '../../core/cache/models/request-param.model';
+import { AuthorizationDataService } from '../../core/data/feature-authorization/authorization-data.service';
+import { FeatureID } from '../../core/data/feature-authorization/feature-id';
+import { FindListOptions } from '../../core/data/find-list-options.model';
+import { PaginatedList } from '../../core/data/paginated-list.model';
+import { RemoteData } from '../../core/data/remote-data';
+import { EPerson } from '../../core/eperson/models/eperson.model';
+import { DSpaceObject } from '../../core/shared/dspace-object.model';
+import { NoContent } from '../../core/shared/NoContent.model';
+import { getFirstCompletedRemoteData } from '../../core/shared/operators';
+import { SearchService } from '../../core/shared/search/search.service';
+import { WorkflowItemDataService } from '../../core/submission/workflowitem-data.service';
+import { WorkspaceitemDataService } from '../../core/submission/workspaceitem-data.service';
+import { hasValue } from '../../shared/empty.util';
+import { NotificationsService } from '../../shared/notifications/notifications.service';
+import { PaginationComponentOptions } from '../../shared/pagination/pagination-component-options.model';
+import { PaginatedSearchOptions } from '../../shared/search/models/paginated-search-options.model';
+import { SearchObjects } from '../../shared/search/models/search-objects.model';
+
+/**
+ * Translation key for the notification shown when an admin tries to delete their own account.
+ * Exported so the templates can bind it as the disabled-delete-button tooltip.
+ */
+export const SELF_DELETE_WARNING_LABEL = 'admin.access-control.epeople.notification.deleted.forbidden.self';
+
+const WARNING_LABEL_PREFIX = 'admin.access-control.epeople.delete.warning.';
+
+/**
+ * Shared logic for the EPerson delete flow used by both the EPeople registry and the EPerson form.
+ * Determines a contextual warning for high-impact deletes, recognises the backend self-delete error
+ * and surfaces the self-delete notification. Centralised here so both call sites stay in sync
+ * (the previous per-component copies had already diverged in their error handling).
+ */
+@Injectable({ providedIn: 'root' })
+export class EPersonDeleteGuardService {
+
+  constructor(
+    private authorizationService: AuthorizationDataService,
+    private workspaceItemDataService: WorkspaceitemDataService,
+    private workflowItemDataService: WorkflowItemDataService,
+    private searchService: SearchService,
+    private notificationsService: NotificationsService,
+    private translateService: TranslateService,
+  ) {
+  }
+
+  /**
+   * Whether the given EPerson is the currently authenticated user.
+   */
+  isCurrentUser(ePerson: EPerson, currentAuthenticatedUserId: string): boolean {
+    return hasValue(ePerson?.id) && ePerson.id === currentAuthenticatedUserId;
+  }
+
+  /**
+   * Resolve the contextual warning translation key for deleting the given EPerson,
+   * or undefined when there is nothing noteworthy to warn about.
+   * Warns when the user has submitted items, is an administrator, or both.
+   */
+  getDeleteWarningLabel(ePerson: EPerson): Observable<string | undefined> {
+    return combineLatest([
+      this.hasSubmittedItems(ePerson.id),
+      this.isAdministrator(ePerson),
+    ]).pipe(
+      map(([hasSubmittedItems, isAdmin]: [boolean, boolean]) => {
+        if (hasSubmittedItems && isAdmin) {
+          return WARNING_LABEL_PREFIX + 'submitterAndAdmin';
+        }
+        if (hasSubmittedItems) {
+          return WARNING_LABEL_PREFIX + 'submitter';
+        }
+        if (isAdmin) {
+          return WARNING_LABEL_PREFIX + 'admin';
+        }
+        return undefined;
+      }),
+    );
+  }
+
+  /**
+   * Whether the backend rejected the delete because an admin tried to delete themselves.
+   */
+  isSelfDeletionError(restResponse: RemoteData<NoContent> | null): boolean {
+    return restResponse?.statusCode === 400 && restResponse?.errorMessage?.toLowerCase().includes('cannot delete yourself');
+  }
+
+  /**
+   * Show the "you cannot delete your own account" error notification.
+   */
+  showSelfDeleteNotification(): void {
+    this.notificationsService.error(this.translateService.get(SELF_DELETE_WARNING_LABEL));
+  }
+
+  /**
+   * Whether the EPerson is the submitter of any workspace, workflow or archived item.
+   * Each lookup degrades to `false` on error so a failed probe never blocks the delete.
+   */
+  private hasSubmittedItems(epersonId: string): Observable<boolean> {
+    const submitterSearchOptions = Object.assign(new FindListOptions(), {
+      currentPage: 1,
+      elementsPerPage: 1,
+      searchParams: [new RequestParam('uuid', epersonId)],
+    });
+    const archivedSearchOptions = new PaginatedSearchOptions({
+      query: `submitter_authority:"${epersonId}"`,
+      pagination: Object.assign(new PaginationComponentOptions(), {
+        currentPage: 1,
+        pageSize: 1,
+      }),
+    });
+
+    return combineLatest([
+      this.workspaceItemDataService.searchBy('findBySubmitter', submitterSearchOptions).pipe(
+        getFirstCompletedRemoteData(),
+        map((rd: RemoteData<PaginatedList<any>>) => rd.hasSucceeded && rd.payload.totalElements > 0),
+        catchError(() => of(false)),
+      ),
+      this.workflowItemDataService.searchBy('findBySubmitter', submitterSearchOptions).pipe(
+        getFirstCompletedRemoteData(),
+        map((rd: RemoteData<PaginatedList<any>>) => rd.hasSucceeded && rd.payload.totalElements > 0),
+        catchError(() => of(false)),
+      ),
+      this.searchService.search<DSpaceObject>(archivedSearchOptions).pipe(
+        getFirstCompletedRemoteData(),
+        map((rd: RemoteData<SearchObjects<DSpaceObject>>) => rd.hasSucceeded && rd.payload.totalElements > 0),
+        catchError(() => of(false)),
+      ),
+    ]).pipe(
+      map((results: boolean[]) => results.some(Boolean)),
+    );
+  }
+
+  /**
+   * Whether the EPerson is a site administrator, via the authorization feature
+   * (catches indirect admin rights and avoids matching on a hard-coded group name).
+   */
+  private isAdministrator(ePerson: EPerson): Observable<boolean> {
+    return this.authorizationService.isAuthorized(FeatureID.AdministratorOf, undefined, ePerson?.id).pipe(
+      catchError(() => of(false)),
+    );
+  }
+}
diff --git a/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.html b/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.html
index ae36b27c87c..1db6b06a0b4 100644
--- a/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.html
+++ b/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.html
@@ -43,10 +43,22 @@ <h1 class="border-bottom pb-2">{{messagePrefix + '.create' | translate}}</h1>
             }
           </div>
         }
-        @if (canDelete$ | async) {
-          <button after class="btn btn-danger delete-button" type="button" (click)="delete()">
-            <i class="fas fa-trash"></i> {{'admin.access-control.epeople.actions.delete' | translate}}
-          </button>
+        @if ((canDelete$ | async) && (activeEPerson$ | async); as activeEPerson) {
+          <span after>
+            @if (isCurrentUser(activeEPerson)) {
+              <span tabindex="0" [ngbTooltip]="selfDeleteWarningLabel | translate" container="body">
+                <button class="btn btn-danger delete-button" [dsBtnDisabled]="true" tabindex="-1" type="button">
+                  <i class="fas fa-trash"></i> {{'admin.access-control.epeople.actions.delete' | translate}}
+                </button>
+              </span>
+            } @else {
+              @if (currentAuthenticatedUserId) {
+                <button class="btn btn-danger delete-button" type="button" (click)="delete()">
+                  <i class="fas fa-trash"></i> {{'admin.access-control.epeople.actions.delete' | translate}}
+                </button>
+              }
+            }
+          </span>
         }
       </ds-form>
 
diff --git a/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.spec.ts b/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.spec.ts
index 6969b44f832..bd170f86fb3 100644
--- a/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.spec.ts
+++ b/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.spec.ts
@@ -64,6 +64,7 @@ import { createPaginatedList } from '../../../shared/testing/utils.test';
 import { FollowLinkConfig } from '../../../shared/utils/follow-link-config.model';
 import { HasNoValuePipe } from '../../../shared/utils/has-no-value.pipe';
 import { EPeopleRegistryComponent } from '../epeople-registry.component';
+import { EPersonDeleteGuardService } from '../eperson-delete-guard.service';
 import { EPersonFormComponent } from './eperson-form.component';
 import { ValidateEmailNotTaken } from './validators/email-taken.validator';
 
@@ -75,6 +76,7 @@ describe('EPersonFormComponent', () => {
   let mockEPeople;
   let ePersonDataServiceStub: any;
   let authService: AuthServiceStub;
+  let deleteGuard: jasmine.SpyObj<EPersonDeleteGuardService>;
   let authorizationService: AuthorizationDataService;
   let groupsDataService: GroupDataService;
   let epersonRegistrationService: EpersonRegistrationService;
@@ -209,6 +211,10 @@ describe('EPersonFormComponent', () => {
       },
     });
     authService = new AuthServiceStub();
+    deleteGuard = jasmine.createSpyObj('deleteGuard', ['isCurrentUser', 'getDeleteWarningLabel', 'isSelfDeletionError', 'showSelfDeleteNotification']);
+    deleteGuard.isCurrentUser.and.callFake((ePerson: EPerson, currentId: string) => !!ePerson?.id && ePerson.id === currentId);
+    deleteGuard.getDeleteWarningLabel.and.returnValue(of(undefined));
+    deleteGuard.isSelfDeletionError.and.returnValue(false);
     authorizationService = jasmine.createSpyObj('authorizationService', {
       isAuthorized: of(true),
 
@@ -238,6 +244,7 @@ describe('EPersonFormComponent', () => {
         { provide: PaginationService, useValue: paginationService },
         { provide: RequestService, useValue: jasmine.createSpyObj('requestService', ['removeByHrefSubstring']) },
         { provide: EpersonRegistrationService, useValue: epersonRegistrationService },
+        { provide: EPersonDeleteGuardService, useValue: deleteGuard },
         { provide: ActivatedRoute, useValue: route },
         { provide: Router, useValue: router },
         EPeopleRegistryComponent,
@@ -490,6 +497,7 @@ describe('EPersonFormComponent', () => {
       modalService = (component as any).modalService;
       spyOn(modalService, 'open').and.returnValue(Object.assign({ componentInstance: Object.assign({ response: of(true) }) }));
       component.ngOnInit();
+      component.currentAuthenticatedUserId = 'different-user-id';
       fixture.detectChanges();
     });
 
@@ -523,6 +531,26 @@ describe('EPersonFormComponent', () => {
       fixture.detectChanges();
       expect(component.epersonService.deleteEPerson).toHaveBeenCalledWith(eperson);
     });
+
+    describe('when the EPerson is the currently authenticated user', () => {
+      beforeEach(() => {
+        component.currentAuthenticatedUserId = eperson.id;
+        fixture.detectChanges();
+      });
+
+      it('should render the delete button as disabled', () => {
+        const deleteButton = fixture.debugElement.query(By.css('.delete-button'));
+        expect(deleteButton.nativeElement.getAttribute('aria-disabled')).toBe('true');
+      });
+
+      it('should notify instead of opening the confirmation modal', () => {
+        spyOn(component.epersonService, 'deleteEPerson').and.returnValue(createSuccessfulRemoteDataObject$('No Content', 204));
+        component.delete();
+        expect(deleteGuard.showSelfDeleteNotification).toHaveBeenCalled();
+        expect(modalService.open).not.toHaveBeenCalled();
+        expect(component.epersonService.deleteEPerson).not.toHaveBeenCalled();
+      });
+    });
   });
 
   describe('Reset Password', () => {
diff --git a/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.ts b/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.ts
index 701684009e8..c2ce7eccd99 100644
--- a/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.ts
+++ b/src/app/access-control/epeople-registry/eperson-form/eperson-form.component.ts
@@ -13,7 +13,10 @@ import {
   Router,
   RouterLink,
 } from '@angular/router';
-import { NgbModal } from '@ng-bootstrap/ng-bootstrap';
+import {
+  NgbModal,
+  NgbTooltipModule,
+} from '@ng-bootstrap/ng-bootstrap';
 import {
   DynamicCheckboxModel,
   DynamicFormControlModel,
@@ -72,6 +75,10 @@ import { PaginationComponentOptions } from '../../../shared/pagination/paginatio
 import { followLink } from '../../../shared/utils/follow-link-config.model';
 import { HasNoValuePipe } from '../../../shared/utils/has-no-value.pipe';
 import { getEPersonsRoute } from '../../access-control-routing-paths';
+import {
+  EPersonDeleteGuardService,
+  SELF_DELETE_WARNING_LABEL,
+} from '../eperson-delete-guard.service';
 import { ValidateEmailNotTaken } from './validators/email-taken.validator';
 
 @Component({
@@ -82,6 +89,7 @@ import { ValidateEmailNotTaken } from './validators/email-taken.validator';
     BtnDisabledDirective,
     FormComponent,
     HasNoValuePipe,
+    NgbTooltipModule,
     PaginationComponent,
     RouterLink,
     ThemedLoadingComponent,
@@ -95,6 +103,9 @@ import { ValidateEmailNotTaken } from './validators/email-taken.validator';
 export class EPersonFormComponent implements OnInit, OnDestroy {
 
   labelPrefix = 'admin.access-control.epeople.form.';
+  selfDeleteWarningLabel = SELF_DELETE_WARNING_LABEL;
+
+  currentAuthenticatedUserId: string;
 
   /**
    * A unique id used for ds-form
@@ -249,6 +260,7 @@ export class EPersonFormComponent implements OnInit, OnDestroy {
     private paginationService: PaginationService,
     public requestService: RequestService,
     private epersonRegistrationService: EpersonRegistrationService,
+    private deleteGuard: EPersonDeleteGuardService,
     public dsoNameService: DSONameService,
     protected route: ActivatedRoute,
     protected router: Router,
@@ -257,6 +269,9 @@ export class EPersonFormComponent implements OnInit, OnDestroy {
 
   ngOnInit() {
     this.activeEPerson$ = this.epersonService.getActiveEPerson();
+    this.subs.push(this.authService.getAuthenticatedUserFromStore().subscribe((currentUser: EPerson) => {
+      this.currentAuthenticatedUserId = currentUser?.id;
+    }));
     this.subs.push(this.activeEPerson$.subscribe((eperson: EPerson) => {
       this.epersonInitial = eperson;
       if (hasValue(eperson)) {
@@ -527,35 +542,57 @@ export class EPersonFormComponent implements OnInit, OnDestroy {
     this.activeEPerson$.pipe(
       take(1),
       switchMap((eperson: EPerson) => {
-        const modalRef = this.modalService.open(ConfirmationModalComponent);
-        modalRef.componentInstance.name = this.dsoNameService.getName(eperson);
-        modalRef.componentInstance.headerLabel = 'confirmation-modal.delete-eperson.header';
-        modalRef.componentInstance.infoLabel = 'confirmation-modal.delete-eperson.info';
-        modalRef.componentInstance.cancelLabel = 'confirmation-modal.delete-eperson.cancel';
-        modalRef.componentInstance.confirmLabel = 'confirmation-modal.delete-eperson.confirm';
-        modalRef.componentInstance.brandColor = 'danger';
-        modalRef.componentInstance.confirmIcon = 'fas fa-trash';
-
-        return modalRef.componentInstance.response.pipe(
+        if (!hasValue(eperson?.id) || !hasValue(this.currentAuthenticatedUserId)) {
+          return of(null);
+        }
+
+        if (this.isCurrentUser(eperson)) {
+          this.deleteGuard.showSelfDeleteNotification();
+          return of(null);
+        }
+
+        return this.deleteGuard.getDeleteWarningLabel(eperson).pipe(
           take(1),
-          switchMap((confirm: boolean) => {
-            if (confirm && hasValue(eperson.id)) {
-              this.canDelete$ = of(false);
-              return this.epersonService.deleteEPerson(eperson).pipe(
-                getFirstCompletedRemoteData(),
-                map((restResponse: RemoteData<NoContent>) => ({ restResponse, eperson })),
-              );
-            } else {
-              return of(null);
-            }
+          switchMap((warningLabel: string | undefined) => {
+            const modalRef = this.modalService.open(ConfirmationModalComponent);
+            modalRef.componentInstance.name = this.dsoNameService.getName(eperson);
+            modalRef.componentInstance.headerLabel = 'confirmation-modal.delete-eperson.header';
+            modalRef.componentInstance.infoLabel = 'confirmation-modal.delete-eperson.info';
+            modalRef.componentInstance.warningLabel = warningLabel;
+            modalRef.componentInstance.cancelLabel = 'confirmation-modal.delete-eperson.cancel';
+            modalRef.componentInstance.confirmLabel = 'confirmation-modal.delete-eperson.confirm';
+            modalRef.componentInstance.brandColor = 'danger';
+            modalRef.componentInstance.confirmIcon = 'fas fa-trash';
+
+            return modalRef.componentInstance.response.pipe(
+              take(1),
+              switchMap((confirm: boolean) => {
+                if (confirm) {
+                  this.canDelete$ = of(false);
+                  return this.epersonService.deleteEPerson(eperson).pipe(
+                    getFirstCompletedRemoteData(),
+                    map((restResponse: RemoteData<NoContent>) => ({ restResponse, eperson, attempted: true })),
+                  );
+                }
+
+                return of({ restResponse: null, eperson, attempted: false });
+              }),
+              finalize(() => this.canDelete$ = of(true)),
+            );
           }),
-          finalize(() => this.canDelete$ = of(true)),
         );
       }),
-    ).subscribe(({ restResponse, eperson }: { restResponse: RemoteData<NoContent> | null, eperson: EPerson }) => {
+    ).subscribe((result: { restResponse: RemoteData<NoContent> | null, eperson: EPerson, attempted: boolean } | null) => {
+      if (!result?.attempted) {
+        return;
+      }
+
+      const { restResponse, eperson } = result;
       if (restResponse?.hasSucceeded) {
         this.notificationsService.success(this.translateService.get(this.labelPrefix + 'notification.deleted.success', { name: this.dsoNameService.getName(eperson) }));
         void this.router.navigate([getEPersonsRoute()]);
+      } else if (this.isCurrentUser(eperson) || this.deleteGuard.isSelfDeletionError(restResponse)) {
+        this.deleteGuard.showSelfDeleteNotification();
       } else {
         this.notificationsService.error(`Error occurred when trying to delete EPerson with id: ${eperson?.id} with code: ${restResponse?.statusCode} and message: ${restResponse?.errorMessage}`);
       }
@@ -563,6 +600,10 @@ export class EPersonFormComponent implements OnInit, OnDestroy {
     });
   }
 
+  isCurrentUser(ePerson: EPerson): boolean {
+    return this.deleteGuard.isCurrentUser(ePerson, this.currentAuthenticatedUserId);
+  }
+
   /**
    * Stop impersonating the EPerson
    */
diff --git a/src/app/shared/confirmation-modal/confirmation-modal.component.html b/src/app/shared/confirmation-modal/confirmation-modal.component.html
index 12789691ea4..a820c1dbf62 100644
--- a/src/app/shared/confirmation-modal/confirmation-modal.component.html
+++ b/src/app/shared/confirmation-modal/confirmation-modal.component.html
@@ -5,6 +5,9 @@
   </div>
   <div class="modal-body">
     <p>{{ infoLabel | translate:{ dsoName: name } }}</p>
+    @if (warningLabel) {
+      <p class="text-warning mb-0">{{ warningLabel | translate:{ dsoName: name } }}</p>
+    }
   </div>
   <div class="modal-footer">
     <button type="button" class="cancel btn btn-outline-secondary" (click)="cancelPressed()" aria-label="Cancel">
diff --git a/src/app/shared/confirmation-modal/confirmation-modal.component.ts b/src/app/shared/confirmation-modal/confirmation-modal.component.ts
index a1a702663e5..e6a44880d78 100644
--- a/src/app/shared/confirmation-modal/confirmation-modal.component.ts
+++ b/src/app/shared/confirmation-modal/confirmation-modal.component.ts
@@ -20,6 +20,7 @@ import { TranslateModule } from '@ngx-translate/core';
 export class ConfirmationModalComponent {
   @Input() headerLabel: string;
   @Input() infoLabel: string;
+  @Input() warningLabel?: string;
   @Input() cancelLabel: string;
   @Input() confirmLabel: string;
   @Input() confirmIcon: string;
diff --git a/src/app/shared/testing/auth-service.stub.ts b/src/app/shared/testing/auth-service.stub.ts
index 121b4bf16e5..424e1bc80f2 100644
--- a/src/app/shared/testing/auth-service.stub.ts
+++ b/src/app/shared/testing/auth-service.stub.ts
@@ -60,6 +60,10 @@ export class AuthServiceStub {
     return of(EPersonMock);
   }
 
+  getAuthenticatedUserFromStore(): Observable<EPerson> {
+    return of(EPersonMock);
+  }
+
   getAuthenticatedUserFromStoreIfAuthenticated(): Observable<EPerson> {
     return of(EPersonMock);
   }
diff --git a/src/assets/i18n/cs.json5 b/src/assets/i18n/cs.json5
index 0e8b47fda3e..a340360dfc2 100644
--- a/src/assets/i18n/cs.json5
+++ b/src/assets/i18n/cs.json5
@@ -548,6 +548,18 @@
   // "admin.access-control.epeople.notification.deleted.success": "Successfully deleted EPerson: \"{{name}}\"",
   "admin.access-control.epeople.notification.deleted.success": "Úspěšně odstraněn uživatel: \"{{name}}\"",
 
+  // "admin.access-control.epeople.notification.deleted.forbidden.self": "You cannot delete your own EPerson account.",
+  "admin.access-control.epeople.notification.deleted.forbidden.self": "Nemůžete smazat svůj vlastní uživatelský účet.",
+
+  // "admin.access-control.epeople.delete.warning.submitter": "Warning: this user has submitted items. Deleting this EPerson may affect submission ownership and related repository records.",
+  "admin.access-control.epeople.delete.warning.submitter": "Upozornění: Tento uživatel vložil do repozitáře záznamy. Jeho smazáním můžete ovlivnit vlastnictví těchto záznamů i souvisejících dat v repozitáři.",
+
+  // "admin.access-control.epeople.delete.warning.admin": "Warning: this user has administrator privileges. Deleting this EPerson will remove an administrator account.",
+  "admin.access-control.epeople.delete.warning.admin": "Upozornění: Tento uživatel má práva správce. Jeho smazáním odeberete účet správce.",
+
+  // "admin.access-control.epeople.delete.warning.submitterAndAdmin": "Warning: this user has submitted items and has administrator privileges. Deleting this EPerson may affect submission ownership and remove an administrator account.",
+  "admin.access-control.epeople.delete.warning.submitterAndAdmin": "Upozornění: Tento uživatel vložil do repozitáře záznamy a má práva správce. Jeho smazáním můžete ovlivnit vlastnictví záznamů a zároveň odeberete účet správce.",
+
   // "admin.access-control.groups.title": "Groups",
   "admin.access-control.groups.title": "Skupiny",
 
diff --git a/src/assets/i18n/en.json5 b/src/assets/i18n/en.json5
index 2cb600f2731..adf1a1d2352 100644
--- a/src/assets/i18n/en.json5
+++ b/src/assets/i18n/en.json5
@@ -349,6 +349,14 @@
 
   "admin.access-control.epeople.form.notification.deleted.failure": "Failed to delete EPerson \"{{name}}\"",
 
+  "admin.access-control.epeople.notification.deleted.forbidden.self": "You cannot delete your own EPerson account.",
+
+  "admin.access-control.epeople.delete.warning.submitter": "Warning: this user has submitted items. Deleting this EPerson may affect submission ownership and related repository records.",
+
+  "admin.access-control.epeople.delete.warning.admin": "Warning: this user has administrator privileges. Deleting this EPerson will remove an administrator account.",
+
+  "admin.access-control.epeople.delete.warning.submitterAndAdmin": "Warning: this user has submitted items and has administrator privileges. Deleting this EPerson may affect submission ownership and remove an administrator account.",
+
   "admin.access-control.epeople.form.groupsEPersonIsMemberOf": "Member of these groups:",
 
   "admin.access-control.epeople.form.table.id": "ID",