diff --git a/CHANGELOG.md b/CHANGELOG.md
index 4bc796cdc6..b5233eabb0 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -8,6 +8,10 @@
 
 ## Unreleased
 
+### Features
+
+- Add `anrProfilingSampleRate` option to profile ANRs on Android ([#6673](https://github.com/getsentry/sentry-react-native/pull/6673))
+
 ### Dependencies
 
 - Bump Cocoa SDK from v9.26.1 to v9.27.0 ([#6670](https://github.com/getsentry/sentry-react-native/pull/6670))
diff --git a/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/react/RNSentryStartTest.kt b/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/react/RNSentryStartTest.kt
index 2b42b0b90e..0c64b573ab 100644
--- a/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/react/RNSentryStartTest.kt
+++ b/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/react/RNSentryStartTest.kt
@@ -400,6 +400,38 @@ class RNSentryStartTest {
         assertEquals(5000L, options.ndkAppHangTimeoutIntervalMillis)
     }
 
+    @Test
+    fun `when anrProfilingSampleRate is set, the ANR profiling sample rate is applied`() {
+        val rnOptions = JavaOnlyMap.of("anrProfilingSampleRate", 0.5)
+        val options = SentryAndroidOptions()
+
+        RNSentryStart.getSentryAndroidOptions(options, rnOptions, logger)
+
+        assertEquals(0.5, options.anrProfilingSampleRate!!, 0.0)
+        assertTrue("ANR profiling should be enabled", options.isAnrProfilingEnabled)
+    }
+
+    @Test
+    fun `when anrProfilingSampleRate is not set, it remains at default (disabled)`() {
+        val rnOptions = JavaOnlyMap()
+        val options = SentryAndroidOptions()
+
+        RNSentryStart.getSentryAndroidOptions(options, rnOptions, logger)
+
+        assertNull("ANR profiling sample rate should be null by default", options.anrProfilingSampleRate)
+        assertFalse("ANR profiling should be disabled by default", options.isAnrProfilingEnabled)
+    }
+
+    @Test
+    fun `when anrProfilingSampleRate is not a number, it is ignored`() {
+        val rnOptions = JavaOnlyMap.of("anrProfilingSampleRate", "invalid")
+        val options = SentryAndroidOptions()
+
+        RNSentryStart.getSentryAndroidOptions(options, rnOptions, logger)
+
+        assertNull("ANR profiling sample rate should remain null", options.anrProfilingSampleRate)
+    }
+
     @Test
     fun `network detail replay options are forwarded to the native replay options`() {
         val mobileReplayOptions =
diff --git a/packages/core/android/src/main/java/io/sentry/react/RNSentryStart.java b/packages/core/android/src/main/java/io/sentry/react/RNSentryStart.java
index 2ee396b239..5e7f750c15 100644
--- a/packages/core/android/src/main/java/io/sentry/react/RNSentryStart.java
+++ b/packages/core/android/src/main/java/io/sentry/react/RNSentryStart.java
@@ -202,6 +202,10 @@ static void getSentryAndroidOptions(
     if (rnOptions.hasKey("enableAnrFingerprinting")) {
       options.setEnableAnrFingerprinting(rnOptions.getBoolean("enableAnrFingerprinting"));
     }
+    if (rnOptions.hasKey("anrProfilingSampleRate")
+        && rnOptions.getType("anrProfilingSampleRate") == ReadableType.Number) {
+      options.setAnrProfilingSampleRate(rnOptions.getDouble("anrProfilingSampleRate"));
+    }
     if (rnOptions.hasKey("enableNdkAppHangTracking")) {
       options.setEnableNdkAppHangTracking(rnOptions.getBoolean("enableNdkAppHangTracking"));
     }
diff --git a/packages/core/src/js/options.ts b/packages/core/src/js/options.ts
index 3780539caf..6b59decd06 100644
--- a/packages/core/src/js/options.ts
+++ b/packages/core/src/js/options.ts
@@ -103,6 +103,21 @@ export interface BaseReactNativeOptions {
    */
   enableAnrFingerprinting?: boolean;
 
+  /**
+   * Sample rate for profiling ANR (Application Not Responding) events.
+   *
+   * When set to a value greater than `0.0`, the SDK profiles the main thread while an ANR is
+   * happening and attaches the resulting profile to the ANR event. The value is the probability
+   * (`0.0`–`1.0`) that any given ANR is profiled.
+   *
+   * Requires ANR detection, which is enabled by default. This is independent of UI/transaction
+   * profiling configured via `profilesSampleRate` and `_experiments.profilingOptions`.
+   *
+   * @default undefined (ANR profiling disabled)
+   * @platform android
+   */
+  anrProfilingSampleRate?: number;
+
   /**
    * When enabled, all the threads are automatically attached to all logged events on Android
    *
diff --git a/packages/core/test/wrapper.test.ts b/packages/core/test/wrapper.test.ts
index dee934f4bd..c98a7527e4 100644
--- a/packages/core/test/wrapper.test.ts
+++ b/packages/core/test/wrapper.test.ts
@@ -177,6 +177,23 @@ describe('Tests Native Wrapper', () => {
       expect(debug.warn).toHaveBeenLastCalledWith('Note: Native Sentry SDK is disabled.');
     });
 
+    test('forwards anrProfilingSampleRate to the Native SDK', async () => {
+      await NATIVE.initNativeSdk({
+        dsn: VALID_DSN,
+        enableNative: true,
+        autoInitializeNativeSdk: true,
+        anrProfilingSampleRate: 0.5,
+        devServerUrl: undefined,
+        defaultSidecarUrl: undefined,
+        mobileReplayOptions: undefined,
+      });
+
+      expect(RNSentry.initNativeSdk).toHaveBeenCalled();
+      // @ts-expect-error mock value
+      const initParameter = RNSentry.initNativeSdk.mock.calls[0][0];
+      expect(initParameter.anrProfilingSampleRate).toBe(0.5);
+    });
+
     test('filter beforeSend when initializing Native SDK', async () => {
       await NATIVE.initNativeSdk({
         dsn: VALID_DSN,