diff --git a/src/plugins/multipart.js b/src/plugins/multipart.js
index 1cd9c6bf..e7ff0a6e 100644
--- a/src/plugins/multipart.js
+++ b/src/plugins/multipart.js
@@ -119,7 +119,9 @@ function createInitMultipart(boundary) {
               if (ctx.name === "partData") {
                 part.transferBuffer += ctx.buffer
                   .slice(ctx.start, ctx.end)
-                  .toString("ascii");
+                  .toString("ascii")
+                  .replaceAll("\r", "")
+                  .replaceAll("\n", "");
 
                 /*
                   four bytes (chars) in base64 converts to three bytes in binary
diff --git a/test/standalone/content-transfer-encoding.test.js b/test/standalone/content-transfer-encoding.test.js
index 567fe994..d638284c 100644
--- a/test/standalone/content-transfer-encoding.test.js
+++ b/test/standalone/content-transfer-encoding.test.js
@@ -1,6 +1,7 @@
 import { join } from "node:path";
 import { createServer, request } from "node:http";
 import { strictEqual } from "node:assert";
+import { PassThrough, Writable } from "node:stream";
 
 import formidable from "../../src/index.js";
 
@@ -60,3 +61,35 @@ test("content transfer encoding", (done) => {
     req.end(body);
   });
 });
+
+test("base64 transfer encoding ignores line breaks", async () => {
+  const body =
+    "--foo\r\n" +
+    'Content-Disposition: form-data; name="file"; filename="file"\r\n' +
+    "Content-Type: application/octet-stream\r\n" +
+    "Content-Transfer-Encoding: base64\r\n" +
+    "\r\n" +
+    "YWJj\r\nZGVm\r\nZ2hp\r\namts\r\n" +
+    "--foo--\r\n";
+  const req = new PassThrough();
+  req.headers = {
+    "content-type": "multipart/form-data; boundary=foo",
+    "content-length": Buffer.byteLength(body),
+  };
+  const chunks = [];
+  const form = formidable({
+    fileWriteStreamHandler: () =>
+      new Writable({
+        write(chunk, _, done) {
+          chunks.push(chunk);
+          done();
+        },
+      }),
+  });
+
+  const parsed = form.parse(req);
+  req.end(body);
+  await parsed;
+
+  strictEqual(Buffer.concat(chunks).toString(), "abcdefghijkl");
+});