diff --git a/NEWS.md b/NEWS.md
index f80bbe9d..170ac4d2 100644
--- a/NEWS.md
+++ b/NEWS.md
@@ -43,6 +43,10 @@
 * `ansi_collapse(style = "head")` no longer exceeds `width` when not even
   the first element fits (#570, @taekop).
 
+* `{.url}` with a substituted value, e.g. `{.url https://example.com/{x}}`,
+  no longer puts ANSI escape sequences into the hyperlink target (#757,
+  @taekop).
+
 * `cli_progress_update(set = )` no longer fails with a deferred `on.exit()`
   error when the progress bar is drawn with a value below zero or above
   the total (#580, @taekop).
diff --git a/R/ansi-hyperlink.R b/R/ansi-hyperlink.R
index ae4054cb..f2c1f6a3 100644
--- a/R/ansi-hyperlink.R
+++ b/R/ansi-hyperlink.R
@@ -310,7 +310,7 @@ make_link_url <- function(txt) {
   if (all(linked)) {
     return(txt)
   }
-  txt[!linked] <- style_hyperlink(txt[!linked], txt[!linked])
+  txt[!linked] <- style_hyperlink(txt[!linked], ansi_strip(txt[!linked]))
   txt
 }
 
diff --git a/tests/testthat/test-links.R b/tests/testthat/test-links.R
index 23f00870..49b9fc08 100644
--- a/tests/testthat/test-links.R
+++ b/tests/testthat/test-links.R
@@ -299,6 +299,18 @@ test_that("make_link_url", {
   expect_equal(make_link_url(x), x)
 })
 
+test_that("{.url} with a substitution has no ANSI in the link target", {
+  withr::local_options(
+    cli.hyperlink = TRUE,
+    cli.ansi = TRUE,
+    cli.num_colors = 256
+  )
+  test <- "path"
+  out <- format_inline("{.url https://example.com/{test}}")
+  target <- sub("^.*?\033\\]8;;([^\a]*)\a.*$", "\\1", out, perl = TRUE)
+  expect_equal(target, "https://example.com/path")
+})
+
 # -- {.vignette} ----------------------------------------------------------
 
 test_that_cli(configs = "plain", links = c("all", "none"), "{.vignette}", {