diff --git a/Cargo.lock b/Cargo.lock
index 0c58a34..1763b36 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -84,7 +84,7 @@ dependencies = [
  "proc-macro2",
  "quote",
  "regex",
- "rustc-hash 2.1.1",
+ "rustc-hash",
  "shlex",
  "syn 2.0.106",
 ]
@@ -158,15 +158,6 @@ dependencies = [
  "parking_lot_core",
 ]
 
-[[package]]
-name = "deranged"
-version = "0.3.11"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b42b6fa04a440b495c8b04d0e71b707c585f83cb9cb28cf8cd0d976c315e31b4"
-dependencies = [
- "powerfmt",
-]
-
 [[package]]
 name = "diff"
 version = "0.1.13"
@@ -255,12 +246,6 @@ version = "0.16.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "5419bdc4f6a9207fbeba6d11b604d481addf78ecd10c11ad51e76c2f6482748d"
 
-[[package]]
-name = "heck"
-version = "0.4.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "95505c38b4572b2d910cecb0281560f54b440a19336cbbcb27bf6ce6adc6f5a8"
-
 [[package]]
 name = "heck"
 version = "0.5.0"
@@ -277,12 +262,6 @@ dependencies = [
  "hashbrown 0.16.0",
 ]
 
-[[package]]
-name = "indoc"
-version = "2.0.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f4c7245a08504955605670dbf141fceab975f15ca21570696aebe9d2e71576bd"
-
 [[package]]
 name = "internment"
 version = "0.8.6"
@@ -442,7 +421,7 @@ dependencies = [
  "libc",
  "libloading",
  "num-complex",
- "paste",
+ "pastey",
  "pkg-config",
  "quil-rs",
  "serde_json",
@@ -493,15 +472,6 @@ version = "2.7.6"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "f52b00d39961fc5b2736ea853c9cc86238e165017a493d1d5c8eac6bdc4cc273"
 
-[[package]]
-name = "memoffset"
-version = "0.9.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "488016bfae457b036d996092f6cb448677611ce4449e970ceaf42695203f218a"
-dependencies = [
- "autocfg",
-]
-
 [[package]]
 name = "minimal-lexical"
 version = "0.2.1"
@@ -581,12 +551,6 @@ dependencies = [
  "num-traits",
 ]
 
-[[package]]
-name = "num-conv"
-version = "0.1.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "51d515d32fb182ee37cda2ccdcb92950d6a3c2893aa280e540671c2cd0f3b1d9"
-
 [[package]]
 name = "num-integer"
 version = "0.1.46"
@@ -618,9 +582,9 @@ dependencies = [
 
 [[package]]
 name = "numpy"
-version = "0.20.0"
+version = "0.29.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bef41cbb417ea83b30525259e30ccef6af39b31c240bda578889494c5392d331"
+checksum = "6a5b15d63a5ff39e378daed0e1340d3a5964703ea9712eb09a0dc66fade996f4"
 dependencies = [
  "libc",
  "ndarray",
@@ -628,7 +592,8 @@ dependencies = [
  "num-integer",
  "num-traits",
  "pyo3",
- "rustc-hash 1.1.0",
+ "pyo3-build-config",
+ "rustc-hash",
 ]
 
 [[package]]
@@ -637,16 +602,6 @@ version = "1.21.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "42f5e15c9953c5e4ccceeb2e7382a716482c34515315f7b03532b8b4e8393d2d"
 
-[[package]]
-name = "parking_lot"
-version = "0.12.4"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "70d58bf43669b5795d1576d0641cfb6fbb2057bf629506267a92807158584a13"
-dependencies = [
- "lock_api",
- "parking_lot_core",
-]
-
 [[package]]
 name = "parking_lot_core"
 version = "0.9.11"
@@ -666,6 +621,12 @@ version = "1.0.15"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "57c0d7b74b563b49d38dae00a0c37d4d6de9b432382b2892f0574ddcae73fd0a"
 
+[[package]]
+name = "pastey"
+version = "0.2.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "2ee67f1008b1ba2321834326597b8e186293b049a023cdef258527550b9935b4"
+
 [[package]]
 name = "petgraph"
 version = "0.6.5"
@@ -688,12 +649,6 @@ version = "1.11.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "f84267b20a16ea918e43c6a88433c2d54fa145c92a811b5b047ccbe153674483"
 
-[[package]]
-name = "powerfmt"
-version = "0.2.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "439ee305def115ba05938db6eb1644ff94165c5ab5e9420d1c1bcedbba909391"
-
 [[package]]
 name = "ppv-lite86"
 version = "0.2.21"
@@ -724,39 +679,33 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.20.3"
+version = "0.29.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "53bdbb96d49157e65d45cc287af5f32ffadd5f4761438b527b055fb0d4bb8233"
+checksum = "4688ddedf473e32662b9b067670129a8afb8c18e351482c70d62ba4a88171e8b"
 dependencies = [
- "cfg-if",
- "indoc",
  "inventory",
  "libc",
- "memoffset",
- "num-complex",
- "parking_lot",
+ "once_cell",
  "portable-atomic",
  "pyo3-build-config",
  "pyo3-ffi",
  "pyo3-macros",
- "unindent",
 ]
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.20.3"
+version = "0.29.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "deaa5745de3f5231ce10517a1f5dd97d53e5a2fd77aa6b5842292085831d48d7"
+checksum = "f41027e41b4bd03f6e60f9f417fe24a6341a6bb744edd62b6f709f2a52ea30e9"
 dependencies = [
- "once_cell",
  "target-lexicon",
 ]
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.20.3"
+version = "0.29.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "62b42531d03e08d4ef1f6e85a2ed422eb678b8cd62b762e53891c05faf0d4afa"
+checksum = "e591a95526fead067432c3b3a33fc74770b87b1e04e73671090d9c2055a2b327"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -764,9 +713,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.20.3"
+version = "0.29.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7305c720fa01b8055ec95e484a6eca7a83c841267f0dd5280f0c8b8551d2c158"
+checksum = "73225868fc1cd84eef2c3c230ddb91273bf1de46aeb8a4248da76d32a0924a1c"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
@@ -776,13 +725,12 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.20.3"
+version = "0.29.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7c7e9b68bb9c3149c5b0cade5d07f953d6d125eb4337723c4ccdb665f1f96185"
+checksum = "571575aa3749fa6216757dd47d2a3e7ef360f329a40f0666a9fbd14889024952"
 dependencies = [
- "heck 0.4.1",
+ "heck",
  "proc-macro2",
- "pyo3-build-config",
  "quote",
  "syn 2.0.106",
 ]
@@ -913,24 +861,14 @@ checksum = "caf4aa5b0f434c91fe5c7f1ecb6a5ece2130b02ad2a590589dda5146df959001"
 
 [[package]]
 name = "rigetti-pyo3"
-version = "0.4.4"
+version = "0.8.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7cd34d8ee532b7e640f53b99286534e6e2f2b80726865c81074dfe44c37e124b"
+checksum = "54283d7a88051a30fd1d508c22a1c5bca9b74ef9572d1e43ee707c5f8417e3d0"
 dependencies = [
- "internment",
- "num-complex",
- "num-traits",
- "paste",
+ "pastey",
  "pyo3",
- "time",
 ]
 
-[[package]]
-name = "rustc-hash"
-version = "1.1.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "08d43f7aa6b08d49f382cde6a7982047c3426db949b1424bc4b7ec9ae12c6ce2"
-
 [[package]]
 name = "rustc-hash"
 version = "2.1.1"
@@ -1075,7 +1013,7 @@ version = "0.26.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "4c6bee85a5a24955dc440386795aa378cd9cf82acd5f764469152d2270e581be"
 dependencies = [
- "heck 0.5.0",
+ "heck",
  "proc-macro2",
  "quote",
  "rustversion",
@@ -1106,9 +1044,9 @@ dependencies = [
 
 [[package]]
 name = "target-lexicon"
-version = "0.12.16"
+version = "0.13.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "61c41af27dd6d1e27b1b16b489db798443478cef1f06a660c96db617ba5de3b1"
+checksum = "adb6935a6f5c20170eeceb1a3835a49e12e19d792f6dd344ccc76a985ca5a6ca"
 
 [[package]]
 name = "thiserror"
@@ -1150,25 +1088,6 @@ dependencies = [
  "syn 2.0.106",
 ]
 
-[[package]]
-name = "time"
-version = "0.3.37"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "35e7868883861bd0e56d9ac6efcaaca0d6d5d82a2a7ec8209ff492c07cf37b21"
-dependencies = [
- "deranged",
- "num-conv",
- "powerfmt",
- "serde",
- "time-core",
-]
-
-[[package]]
-name = "time-core"
-version = "0.1.2"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ef927ca75afb808a4d64dd374f00a2adf8d0fcff8e7b184af886c3c87ec4a3f3"
-
 [[package]]
 name = "typenum"
 version = "1.18.0"
@@ -1181,12 +1100,6 @@ version = "1.0.19"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "f63a545481291138910575129486daeaf8ac54aee4387fe7906919f7830c7d9d"
 
-[[package]]
-name = "unindent"
-version = "0.2.4"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7264e107f553ccae879d21fbea1d6724ac785e8c3bfc762137959b5802826ef3"
-
 [[package]]
 name = "version_check"
 version = "0.9.5"
diff --git a/Cargo.toml b/Cargo.toml
index c15f290..7650574 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -1,3 +1,23 @@
 [workspace]
 resolver = "2"
 members = ["lib", "python"]
+
+[workspace.dependencies]
+assert2 = "0.3.11"
+bindgen = "0.72"
+cc = "1.0"
+libc = "0.2"
+libloading = "0.8.0"
+libquil-sys = { path = "lib" }
+num-complex = "0.4.4"
+pastey = "0.2"
+pkg-config = "0.3"
+quil-rs = "0.32.0"
+serde_json = "1.0.105"
+thiserror = "2.0"
+
+# PyO3 dependencies (must be kept compatible with each other)
+pyo3 = "0.29"
+pyo3-build-config = "0.29"
+numpy = "0.29"
+rigetti-pyo3 = "0.8"
diff --git a/lib/Cargo.toml b/lib/Cargo.toml
index d347ed9..5793d7b 100644
--- a/lib/Cargo.toml
+++ b/lib/Cargo.toml
@@ -15,20 +15,20 @@ readme = "../README.md"
 # See more keys and their definitions at https://doc.rust-lang.org/cargo/reference/manifest.html
 
 [dependencies]
-libc = "0.2"
-libloading = "0.8.0"
-num-complex = "0.4.4"
-serde_json = "1.0.105"
-thiserror = "2.0"
-paste = "1.0.6"
+libc = { workspace = true }
+libloading = { workspace = true }
+num-complex = { workspace = true }
+serde_json = { workspace = true }
+thiserror = { workspace = true }
+pastey = { workspace = true }
 
 [build-dependencies]
-cc = { version = "1.0", features = ["parallel"] }
-pkg-config = "0.3"
-bindgen = "0.72"
-thiserror = "2.0"
+cc = { workspace = true, features = ["parallel"] }
+pkg-config = { workspace = true }
+bindgen = { workspace = true }
+thiserror = { workspace = true }
 
 [dev-dependencies]
-assert2 = "0.3.11"
-quil-rs = "0.32.0"
+assert2 = { workspace = true }
+quil-rs = { workspace = true }
 
diff --git a/lib/src/quilc.rs b/lib/src/quilc.rs
index 2b7ac51..c879ffc 100644
--- a/lib/src/quilc.rs
+++ b/lib/src/quilc.rs
@@ -219,7 +219,7 @@ macro_rules! get_metadata_field {
             let mut var = $field_type::default();
             let mut present = 0;
 
-            paste::paste!(
+            pastey::paste!(
             let err = [<quilc_compilation_metadata_get_ $field_name>](
                 $metadata_ptr,
                 std::ptr::addr_of_mut!(var) as *mut _,
diff --git a/python/Cargo.toml b/python/Cargo.toml
index b4650d4..4f1c3f2 100644
--- a/python/Cargo.toml
+++ b/python/Cargo.toml
@@ -8,12 +8,12 @@ name = "libquil"
 crate-type = ["cdylib", "rlib"]
 
 [dependencies]
-libloading = "0.8.0"
-libquil-sys = { path = "../lib" }
+libloading = { workspace = true }
+libquil-sys = { workspace = true }
 # pyo3 dependencies should be updated together
-numpy = { version = "0.20" }
-pyo3 = { version = "0.20", features = ["extension-module"] }
-rigetti-pyo3 = "0.4"
+numpy = { workspace = true }
+pyo3 = { workspace = true, features = ["extension-module"] }
+rigetti-pyo3 = { workspace = true }
 
 [build-dependencies]
-pyo3-build-config = { version = "0.20" }
+pyo3-build-config = { workspace = true }
diff --git a/python/src/chip.rs b/python/src/chip.rs
index 59d5401..9c41878 100644
--- a/python/src/chip.rs
+++ b/python/src/chip.rs
@@ -1,20 +1,15 @@
 use pyo3::prelude::*;
-use pyo3::types::PyString;
 
-use rigetti_pyo3::{py_wrap_struct, ToPythonError};
+#[pyclass(name = "Chip", unsendable)]
+pub struct PyChip(pub(crate) libquil_sys::quilc::Chip);
 
-#[derive(Clone)]
-pub struct Chip(pub(crate) libquil_sys::quilc::Chip);
-
-py_wrap_struct! {
-    PyChip(Chip) as "Chip" {
-        py -> rs {
-            str: Py<PyString> => Chip {
-                let s = str.as_ref(py).to_str()?;
-                let lc: libquil_sys::quilc::Chip = s.parse().map_err(|err| crate::RustLibquilQuilcError::from(err).to_py_err())?;
-                let c: Chip = Chip(lc);
-                Ok::<_, PyErr>(c)
-            }
-        },
+#[pymethods]
+impl PyChip {
+    #[new]
+    pub fn new(s: &str) -> PyResult<Self> {
+        let chip: libquil_sys::quilc::Chip = s
+            .parse()
+            .map_err(|err| PyErr::from(crate::RustLibquilQuilcError::from(err)))?;
+        Ok(Self(chip))
     }
 }
diff --git a/python/src/compile.rs b/python/src/compile.rs
index 0852c47..0a7dbc4 100644
--- a/python/src/compile.rs
+++ b/python/src/compile.rs
@@ -1,27 +1,31 @@
-use pyo3::{exceptions::PyValueError, prelude::*, types::PyBool};
-use rigetti_pyo3::{py_wrap_data_struct, PyWrapper, ToPythonError};
+use pyo3::{exceptions::PyValueError, prelude::*};
 
-#[derive(Clone)]
-pub struct CompileOptions {
+#[pyclass(name = "CompileOptions", skip_from_py_object)]
+#[derive(Debug, Clone, Default)]
+pub struct PyCompileOptions {
     pub protoquil: Option<bool>,
 }
 
-py_wrap_data_struct! {
-    PyCompileOptions(CompileOptions) as "CompileOptions" {
-        protoquil: Option<bool> => Option<Py<PyBool>>
-    }
-}
-
 #[pymethods]
 impl PyCompileOptions {
     #[new]
-    pub fn new(py: Python<'_>, protoquil: Option<Py<PyBool>>) -> PyResult<Self> {
-        let protoquil = protoquil.map(|p| p.is_true(py)).transpose()?;
-        Ok(Self(CompileOptions { protoquil }))
+    #[pyo3(signature = (protoquil=None))]
+    pub fn new(protoquil: Option<bool>) -> Self {
+        Self { protoquil }
+    }
+
+    #[getter]
+    pub fn get_protoquil(&self) -> Option<bool> {
+        self.protoquil
+    }
+
+    #[setter]
+    pub fn set_protoquil(&mut self, protoquil: Option<bool>) {
+        self.protoquil = protoquil;
     }
 }
 
-#[pyclass(name = "CompilationMetadata")]
+#[pyclass(name = "CompilationMetadata", skip_from_py_object)]
 #[derive(Debug, Clone)]
 pub struct PyCompilationMetadata(libquil_sys::quilc::CompilationMetadata);
 
@@ -94,14 +98,14 @@ pub fn compile(
     chip: &crate::chip::PyChip,
     options: Option<&PyCompileOptions>,
 ) -> PyResult<PyCompilationResult> {
-    let protoquil = options.and_then(|e| e.as_inner().protoquil);
+    let protoquil = options.and_then(|e| e.protoquil);
 
     let compilation_result = if let Some(true) = protoquil {
-        libquil_sys::quilc::compile_protoquil(&program.as_inner().0, &chip.as_inner().0)
-            .map_err(|e| crate::RustLibquilQuilcError::from(e).to_py_err())?
+        libquil_sys::quilc::compile_protoquil(&program.0, &chip.0)
+            .map_err(|e| PyErr::from(crate::RustLibquilQuilcError::from(e)))?
     } else {
-        libquil_sys::quilc::compile_program(&program.as_inner().0, &chip.as_inner().0)
-            .map_err(|e| crate::RustLibquilQuilcError::from(e).to_py_err())?
+        libquil_sys::quilc::compile_program(&program.0, &chip.0)
+            .map_err(|e| PyErr::from(crate::RustLibquilQuilcError::from(e)))?
     };
 
     let metadata = compilation_result.metadata.map(PyCompilationMetadata);
diff --git a/python/src/lib.rs b/python/src/lib.rs
index 9cef4b0..0738ff1 100644
--- a/python/src/lib.rs
+++ b/python/src/lib.rs
@@ -4,26 +4,43 @@ mod program;
 
 use pyo3::prelude::*;
 
-use rigetti_pyo3::{create_init_submodule, py_wrap_error, wrap_error};
+use rigetti_pyo3::{create_init_submodule, exception};
 
-wrap_error! {
-    RustLibquilQuilcError(libquil_sys::quilc::Error)
+/// Newtype around [`libquil_sys::quilc::Error`] so it can be converted into a
+/// Python exception (the orphan rule forbids implementing `From` for the
+/// foreign error type directly).
+#[derive(Debug)]
+pub struct RustLibquilQuilcError(libquil_sys::quilc::Error);
+
+impl From<libquil_sys::quilc::Error> for RustLibquilQuilcError {
+    fn from(err: libquil_sys::quilc::Error) -> Self {
+        Self(err)
+    }
+}
+
+impl std::fmt::Display for RustLibquilQuilcError {
+    fn fmt(&self, f: &mut std::fmt::Formatter<'_>) -> std::fmt::Result {
+        std::fmt::Display::fmt(&self.0, f)
+    }
 }
 
-py_wrap_error!(
-    libquil,
+impl std::error::Error for RustLibquilQuilcError {}
+
+exception!(
     RustLibquilQuilcError,
+    "libquil",
     PyLibquilError,
     pyo3::exceptions::PyException
 );
 
 #[pymodule]
-fn libquil(py: Python<'_>, m: &PyModule) -> PyResult<()> {
+fn libquil(py: Python<'_>, m: &Bound<'_, PyModule>) -> PyResult<()> {
     init_submodule("libquil", py, m)?;
     Ok(())
 }
 
 create_init_submodule! {
     classes: [chip::PyChip, program::PyProgram, compile::PyCompileOptions],
+    errors: [PyLibquilError],
     funcs: [compile::compile],
 }
diff --git a/python/src/program.rs b/python/src/program.rs
index 35b66af..33798db 100644
--- a/python/src/program.rs
+++ b/python/src/program.rs
@@ -1,18 +1,15 @@
 use pyo3::prelude::*;
-use pyo3::types::PyString;
-use rigetti_pyo3::{py_wrap_struct, ToPythonError};
 
-#[derive(Clone)]
-pub struct Program(pub(crate) libquil_sys::quilc::Program);
+#[pyclass(name = "Program", unsendable)]
+pub struct PyProgram(pub(crate) libquil_sys::quilc::Program);
 
-py_wrap_struct! {
-    PyProgram(Program) as "Program" {
-        py -> rs {
-            str: Py<PyString> => Chip {
-                let s = str.as_ref(py).to_str()?;
-                let program = s.parse().map_err(|err| crate::RustLibquilQuilcError::from(err).to_py_err())?;
-                Ok::<_, PyErr>(Program(program))
-            }
-        },
+#[pymethods]
+impl PyProgram {
+    #[new]
+    pub fn new(s: &str) -> PyResult<Self> {
+        let program: libquil_sys::quilc::Program = s
+            .parse()
+            .map_err(|err| PyErr::from(crate::RustLibquilQuilcError::from(err)))?;
+        Ok(Self(program))
     }
 }