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Course material for STA426 fall semester 2026

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Statistical Analysis of High-Throughput Genomic and Transcriptomic Data

Fall/Herbst-semester 2026

Lectures

Mondays 9.00-9.45 (Y27-H-46), 10.00-10.45 (Y27-H-46)

Exercises

Monday 11.00-11.45

Lecturers

Dr. Hubert Rehrauer, Group Leader of Genome Informatics at FGCZ

Prof. Dr. Mark Robinson, Professor of Statistical Genomics, DMLS, UZH

tba

Schedule

Date Lecturer Topic Exercise JC1 JC2
14.09.2026 Mark+Hubert admin; mol. bio. basics quarto; git(hub)
21.09.2026 Hubert NGS intro; exploratory data analysis EDA in R
28.09.2026 Hubert mapping Rsubread
05.10.2026 Mark limma + friends linear model simulation + design matrices
12.10.2026 Hubert RNA-seq quantification RSEM
19.10.2026 Mark hands-on session #1: benchmarking group exercise: Omnibenchmark ROTS: reproducible RNA-seq biomarker detector––prognostic markers for clear cell renal cell cancer (SS,FO) X
26.10.2026 Mark edgeR+friends 1 basic edgeR/voom scMultiMap: Cell-type-specific mapping of enhancers and target genes from single-cell multimodal data (MS, TP) X
02.11.2026 Mark edgeR+friends 2 advanced edgeR/voom X X
09.11.2026 Mark hands-on session #2: RNA-seq FASTQC/Salmon/etc. X X
16.11.2026 Hubert single-cell 1: preprocessing, dim. red., clustering clustering X X
23.11.2026 Mark single-cell 2: clustering, marker gene DE marker gene DE X X
<<<<<<< Updated upstream
30.11.2026 Mark spatial omics 1 spatial statistics X Efficient differential expression analysis of large-scale single-cell transcriptomics data using Dreamlet (GK, WR)
=======
30.11.2026 Mark spatial omics 1 spatial statistics X (GK, WR)

Stashed changes | 07.12.2026 | tba | hands-on session #3: single-cell RNA-seq | full scRNA-seq pipeline | X | X | | 14.12.2026 | Mark | spatial omics 2 | structures, DSP | X | X |

Course material

Assuming you have git installed locally, you can check out the entire set of course materials with the following command (from command line):

git clone https://github.com/sta426hs2026/material.git

and get updates by running git pull at any later time in the same directory.

Alternatively, to retrieve a ZIP file of the repository, you can click on the (green) 'Code' button (top right of main panel) and then click 'Download ZIP'.

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Course material for STA426 fall semester 2026

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